Bioreducible Hyperbranched Poly(amido amine)s for Gene Delivery
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چکیده
منابع مشابه
Bioreducible Polymer Nanosystems For Gene Delivery
...........................................................................................................................157 Autobiographical Statement.................... ........................................................................159
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Intracellular processes, including endosomal escape and intracellular release, are efficiency-determining steps in achieving successful gene delivery. It has been found that the presence of acid-labile units in polymers can facilitate endosomal escape and that the presence of reducible units in polymers can lead to intracellular release. In this study, poly(amido amine)s with both bioreducible ...
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Recently, non-viral vectors for nucleic acid delivery have received considerable attention. Among the various non-viral vectors, branched polyethylenimine (bPEI, 25 kDa) has been one of the most widely used carrier systems due to its high transfection efficiency, however, it imparts high cytotoxicity. In this study, we have crosslinked bPEI with a bioreducible linker, 3,3'-dithiodipropionic aci...
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ژورنال
عنوان ژورنال: Biomacromolecules
سال: 2009
ISSN: 1525-7797,1526-4602
DOI: 10.1021/bm900724c